Morgellons Disease and Mucocutaneous Splendore-Hoeppli phenomenon

Several members at Morgellons Disease forums are seeing a strong resemblance with their symptoms/specimens by comparing their pictures with the in vivo formation of eosinophilic material such as radiate, club-shaped and stellate-shaped  configurations of the Mucocutaneous Splendore-Hoeppli phenomenon.

Many sufferers which have seeked helped by their doctors have reported that after blood tests have been conducted, the so called Eosinophilic titers haven’t shown any abnormalities, leading doctors to the wrong diagnosis and conclusions stating no infectious material nor antibodies found.

I’m stating that the Mucocutaneous Splendore-Hoeppli phenomenon might play a significant role in Morgellons Disease.

Astonishing is also the  fact that according to this phenomenom, the body is unable to recognize pathogens. At the end the infection becomes chronic, either bacterial, fungal or parasitic.

What is the Spendore-Hoeppli phenomenom

Splendore-Hoeppli phenomenon (asteroid bodies) is the in vivo formation of intensely eosinophilic material (radiate, star-like, asteroid or club-shaped configurations) around microorganisms (fungi, bacteria and parasites) or biologically inert substances.

Mucocutaneous infections and the non-infective diseases are associated with it. Available studies indicate that several mucocutaneous infections can generate Splendore-Hoeppli reaction.

Although the exact nature of this reaction is unknown, it is thought to be a localized immunological response to an antigen-antibody precipitate related to fungi, parasites, bacteria or inert materials.

The characteristic formation of the peribacterial or perifungal Splendore-Hoeppli reaction probably prevents phagocytosis and intracellular killing of the insulting agent leading to chronicity of infection.

Fungal infections include sporotrichosis, pityrosporum folliculitis, zygomycosis, candidiasis, aspergillosis and blastomycosis.

The bacterial infections include botryomycosis, nocardiosis and actinomycosis.

The parasitic conditions include orbital pythiosis, strongyloidiasis, schistosomiasis and cutaneous larva migrans.

In addition, Splendore-Hoeppli reaction may be seen with non-infective pathology such as hypereosinophilic syndrome and allergic conjunctival granulomas.

The Splendore-Hoeppli reaction material comprises antigen-antibody complex, tissue debris and fibrin.

To conclude, Splendore-Hoeppli reaction is a tell tale of a spectrum of infections and reactive conditions.

The molecular pathways involved in the development of this reaction are open for future investigations.

Actinomycetes, a bacterial infection with typical MSH-phenomenom formations

Actinomycetes, initially identified to be a fungus due to it’s filamentous appearance, is actually a high form of bacteria. Actinomycetes shows also different forms such as filaments, star-shaped or club-shaped.

Another aspect of this infection that shows strong resemblance in Morgellons sufferers are the yellow granules…

Many people affected by this disease have mentioned a ‘yellow goo’ extract from their lesions (sulfur is yellow), also white and black specks.

The following pictures are showing typical forms of Actinomycetes:

Sphere form:

Also note it’s filamentous and stellate form:

Gelatinous form with ‘black specks’:

Picture of cultured Actinomycetes:

Actinomycetes is also known to infect the female genital tract, but can also be systemic…causing lung problems for example.

‘Both actinomycotic granules and pseudoactinomycotic radiate granules (PAMRAGs) occur in the female genital tract, most commonly in the endometrium.

The combined granules consisted of central basophilic Gram and silver positive filamentous organisms consistent with actinomyces surrounded by radiating eosinophilic club-like formations which were Gram and silver negative, the latter consistent with PAMRAGs. The PAMRAGs in the cervix and vulva consisted entirely of Gram and silver negative radiating eosinophilic club-like formations’.

Another aspect to consider is that Actinomycetes cause disease also in animals such as cows, sheep and dogs..etc…which could be the connection to pets with Morgellons and/or assumed contagiousness.

References:

http://www.ncbi.nlm.nih.gov/pubmed/18976399

http://www.nyccompost.org/science/science4.html

http://www.uni-giessen.de/~gh1484/actino.html

http://www.saber.ula.ve/tropical/contenido/capitulo12/capitulo62/contenidocapitulo-en.html

http://jcp.bmj.com/content/62/12/1123.abstract

~ by k&k on January 10, 2010.

One Response to “Morgellons Disease and Mucocutaneous Splendore-Hoeppli phenomenon”

  1. I WAS DIAGNOSED WITH FORMATION SND THE DR SAID HE COULD NOT DIAGNOSE ME WITH MORGELLONS BECAUSE IT IS NOT A SO CALLED DISEASE YET ACCORDIG TO THE CDC. I HAVE MORE OF THE BLACK SPECKS OR BLACK PARTICLES THAT ARE ATTACHED TO RHE SCAB OF MY LESIONS AND IF THE SCAB IS REMOVED THE BLACK PARTICLES SURROUND THE SCAB AND ALSO STILL ON THE LESION. I NOTICED SOME OF THE SCABS THAT FORM ON THE LESIONS ARE VERY STRANGE THEY ARE VERY THIN AND LOOK LIKE A FIE PIECE OF CARDBOARD AND WHEN REMOVED THE SCAB COMES OFF IN ONE PIECE THEN WHEN IT STARTS TO DRY IT CURLS UP ON BOTH ENDS(HAVE YOU HEARD OF THIS BEFORE) AND WHEN I LOOK AT THE SCAB UDER A MAGNIFING GLASS THE SCAB LOOKS LIKE A THIN PIECE OF BROWN PAPER AND THE SCAB IS VERY FLAT AND FINE IN SHAPE. I ALSO SEE WHEN A SCAB COME OFF PARTICLES THAT RANGE IN COLOR FROM BROWN TO A LIGHT YELLOW TO A GOLDEN OR REDDISH COLOR AND HAVE PARTICLES THAT LOOK LIKE SEEDS AND WHEN I SQUEEZE THEM WITH TWEEZERS A LITTLE SEED LOOKING PARTICLE COMES OUT. I REALLY HAVENT SEEN ANY THREAD LIKE OR FUZZ BALL LOOKING PARTICLES COME OUT OF MY BODY BUT MAYBE A FEW TIMES. I HAVE LEASIONS ALL OVER MY BODY EXPECIALLY MY FACE AND WHEN THEY TRY TO HEAL I CAN STILL FEEL THE FORMATION UNDER MY SKIN AND MY SKIN HAS BECOME THICK IN THOSE AREAS AND IF I TRY TO REMOVE THEM WITH TWEEZERS ITS VERY TOUGH TO EVEN GET OFF BUT WHENIT DOES THE SKIN WILL COME OFF IN BIG PIECES OR STRIPS AND THE SKIN IS VERY VERY THICK, DO YOU KNOW HOW I CAN GET MY SKIN ON MY FACE TO BECOME THINNER WHERE IT IS VERY THICK? WHEN I PUT MAKE UP ON ITS VERY OBVIOUS THAT IN THOSE AREAS THE SKIN IS ALOT THICKER AND MOST OF THE TIME WHEN THE LESIONS ARE TRYING TO HEAL THEY GET SO DRY AND THEY CRACK IF I LAUFG OR OPEN MY MOUTH WIDE AND THEY START TO BLEED AND THIS ALSO LOOKS BAD WHEN I TRY TO COVER THE LESIONS WITH MAKEUP. IS THERE SOMETHING I CAN BUY THAT WILL REMOVE THE VERY DRY SKIN WHEN THIS HAPPENS I TRYED TO USE AN EXFOLIATE SOAP OR XLEANSER AND IT DOESNT EVEN DO ANYTHING SINCE THE SKIN IS SO HARD TO REMOVE EXPECIALLY IN THE THICK AREAS. I HAVE EVEN THOUGHT OF USING SANDPAPER OR A FILE TO EVEN OUT MY SKIN ON MY FACE SO MAKEUP WONT LOOK SO BAD BUT IM SCARED TO USE ANYTHIN LIKE THAT ON MY FACE BUT BELIEVE ME ITS GETTING TO THAT POINT BECAUSE I CANT FIND ANYTHIN THAT WILL REMOVE THE VERY DRY AND THICK SKIN BECAUSE ITS TO HARD TO REMOVE EVEN WITH TWEEZERS AND THEY HURT SO BAD SOMETIMES IT FEELS LIKE MY FACE IS ON FIRE AND ANYTHING I PUT ON MY FACE DURING THAT TIME MAKES IT TWICE AS BAD EVEN WATER, I HAVE TRIED LOTIONS SUCH AS MEDERMA AND OTHER SKIN LOTIONS BUT NOTHING WORKS, I HAVE ALSO WASHED MY FACE WITH THIS OVER THE COUNTER PSORISIS SOAP WHICH IS SUPPOSED TO CLEAN THE AREA VERY WELL AND HELP IN THE HEALIG PROCESS BUT IT REALLY DOESNT WORK EITHER IT JUST MAKES MY SKIN BURN. I NEED TO FIND SOMETHING TAT WILL HELP MY LEASIONS HEAL FASTER AND SOMETHING THAT WILL REMOVE THE OLD DRY SKIN THATS SO HARD TO REMOVE, ANY SUGGESTIONS? PLEASE EMAIL ME WITH ANY INFORMATION YOU MAY HAVE REGARDING EITHER OVER THE COUNTER OR RX MEDICATIOS OR LOTIONS THAT WILL HELP ME. THANKS GRACE ENSEY

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