Lysosomes – Magnesium – Potassium – Calcium Beneficial for Morgellons Sufferers?

As our research has revealed we believe that this insect virus, the Baculovirus,  is the causative agent of Morgellons Disease.

We are stating that the Baculovirus is capable to ‘dock’ on to human cells.

Research on this subject has shown that high Magnesium and high Potassium levels are the ‘key’ in eliminating the virus respectively inhibiting further re-production.

My own experience in using these supplements, also adding higher doses of zinc, has lead me to the strong belief that these were beneficial in treating this disease as my symptoms have decreased tremendously.

Here are a few excerpts that will show how I came to the above conclusions:

“The Baculovirus is able to enter human hepatoma cells.”

“Autographa californica multiple nucleopolyhedrovirus (AcMNPV), a prototype member of the Baculoviridae family, has gained increasing interest as a potential vector candidate for mammalian gene delivery applications.”

“The host specificity of baculovirus was long supposed to be restricted to arthropods until Volkman and Goldsmith (53) showed that the viruses were efficiently taken up by mammalian cells. Later, Hofmann and colleagues (22) reported that the recombinant baculoviruses were also able to deliver genes into human hepatocytes.”

“Entry of baculovirus to mammalian cells has been thought to be similar to that found in insect cells. Cell surface molecule interactions with baculovirus during uptake in mammalian cells are unclear; however, the virus has been suggested to use rather widely distributed and heterogeneous cell surface motifs (14). The first evidence for use of the endosomal pathway during baculovirus entry was provided by transducing cells in the presence of chloroquine, bafilomycin A1, and ammonium chloride, which all strongly prevented viral transduction.”

“The early events of a viral infection include attachment of the virion to the receptor followed by entry into the cell and subsequent release of the genome. Despite numerous efforts, the natural receptor for baculovirus has not yet been discovered. Because of the wide range of mammalian cells that are susceptible to baculovirus transduction, it is likely that the target molecule is a relatively universal cell surface component, possibly heparan sulfate or even a phospholipid.”

In conclusion, these data indicate that baculovirus uses at least clathrin-mediated endocytosis as one of its entry pathways to HepG2 cells. However, baculovirus attachment to clathrin-coated pits seemed to be a relatively rare phenomenon, and therefore other internalization mechanisms could also coexist.”

“Clathrin-mediated endocytosis is known to lead to early and late endosomes, and finally to lysosomes (35). So far, many different viruses have been shown to utilize this pathway for release of the viral capsid to the cytoplasm from the early or late endosomes in mammalian cells.”

“The size difference between clathrin-coated vesicles (100 to 150 nm; (35) and baculoviruses (25 x 260 nm) is likely to restrict viral entry via clathrin-mediated endocytosis into mammalian cells.”

“Interestingly, Bilello et al. (4) have suggested that baculovirus entry to primary hepatocytes may require contact with the basolateral surface, which contains numerous microvilli (2). The occlusion-derived baculovirus has also been shown to fuse with the microvillar membrane of columnar epithelial cells in the highly alkaline midgut environment at low temperatures (38). In this study, baculovirus seemed to induce formation of microvilli and resided primarily on those areas of the cell surface (Fig. 3D). The higher occurrence of microvilli-like structures in virus-treated cells than in control cells may support the use of the macropinocytosis route in baculovirus entry.”

“In summary, our results suggest that baculovirus entry into human hepatoma cells is a relatively slow process, probably due to the large size of the virus. Electron microscopy analysis showed viruses at the following multiple cellular locations: at the cell surface, in clathrin-coated pits, in early endosomes, and in intracellular vesicles resembling macropinosomes. In confocal microscopy and nanogold preembedding electron microscopy, the baculovirus particles were shown to colocalize with early and late endosomal/lysosomal markers. These results suggest that baculovirus may enter mammalian cells by both clathrin-mediated endocytosis and macropinocytosis.”

What are Lysosomes?

“Lysosomes are organelles containing digestive enzymes (acid hydrolases). They are found in animal cells, while in plant cells the same roles are performed by the vacuole. They digest excess or worn-out organelles, food particles, and engulfed viruses or bacteria. The membrane surrounding a lysosome allows the digestive enzymes to work at the 4.5 pH they require. Lysosomes fuse with vacuoles and dispense their enzymes into the vacuoles, digesting their contents.”

image

Proteins in different cellular compartments and structures tagged with green fluorescent protein.

“Lysosomes are used for the digestion of macromolecules from phagocytosis (ingestion of other dying cells or larger extracellular material, like foreign invading microbes), endocytosis (where receptor proteins are recycled from the cell surface), and autophagy (wherein old or unneeded organelles or proteins, or microbes that have invaded the cytoplasm are delivered to the lysosome). Autophagy may also lead to autophagic cell death, a form of programmed self-destruction, or autolysis, of the cell, which means that the cell is digesting itself.

Other functions include digesting foreign bacteria (or other forms of waste) that invade a cell and helping repair damage to the plasma membrane by serving as a membrane patch, sealing the wound.”

Lysosomes are digestive enzymes as stated above. I personally think that buffering the ph level is essential to keep the body functions intact in order to control the symptoms of Morgellons Disease.

Magnesium,Potassium and Calcium

“Magnesium, the second most abundant intracellular cation, is a catalytic and structural element of major significance in the physiology of the human organism. Necessary for the anatomical and functional integrity of various subcellular organelles, it participates in all the major metabolic pathways, i.e., those involving carbohydrates, proteins and lipids, as well as in redox reactions. It is involved in the regulation of ion levels, maintaining the potassium level in the cell and exercising on the metabolism of calcium and phosphorus vitamin D-like effects.

Integral to processes of defense, magnesium exhibits a variety of effects: antistress, anti-allergic, anti-anaphylactic, anti-inflammatory, antiradiation. Magnesium plays a role in thermoregulation; it stimulates phagocytosis and the formation of antibodies, complement and elements of the properdin system.

Present in many tissues, it is active in the physiology of many systems, not only neuromuscular, osteo-articulatory, and dental, but also respiratory, endocrine, reproductive, ocular, digestive, hepatic, pancreatic, renal, cardiovascular and hematologic.”

“Magnesium also appears to protect lysosomes. Magnesium deficit in the rat, for example, is accompanied by a degranulation of mast cells that may be compared to the degranulation of polynuclear basophils in man. This is not the result of a degranulating factor in serum, but rather of a direct cellular effect of magnesium deficit, perhaps a reduction in the level of cAMP.”

“Magnesium thus acts as a major cellular and subcellular stabilizing agent which is necessary for the stability of plasma membranes, for the integrity of mitochondria, lysosomes, polysomes, and chromosomes as well as for the integrity of the helix of DNA and of messenger RNA and of RNA complexes.”

“The effects of magnesium on leucocytes — enhancing phagocytosis and the production of lymphocytes and their transformation into blast cells while moderating the inflammatory reaction (342, 349) — are less important in the analysis of the effects of magnesium deficit on the formed elements of the blood as a vascular risk factor than are its stabilizing effects on platelets and erythrocytes.

Magnesium deficit, on the other hand, favors vascular disease by its effects on the metabolism of phosphorus and calcium in calcinosis, on the metabolism of proteins, carbohydrates and glycoproteins in alterations analogous to connective tissue changes due to aging and finally on the metabolism of lipids and lipoproteins by enhancing atherogenic dyslipidemias “

“Magnesium deficiency produces a true “aging” of bone with a slowed turnover of bone cells and a reduced receptivity to the hormone-like D vitamins as well as to parathyroid hormone. Magnesium deficiency affects the teeth before affecting skeletal bones.”

Many Morgellons Sufferers have reported to have problems with their teeth and gums. Interesting is also the fact that Morgellons Sufferers have reported to have an exceedingly ‘craving’ for milk or milk products.

“Magnesium deficiency produces low magnesium levels in the extra-cellular compartment and a reduction of levels in the cell along with hyperpermeability of the cell membrane. This depolarisation finally causes a lowered level of cellular potassium and a calcium overload (increase of intracellular Ca), in conjunction with a lowering of phosphorus levels and an increase in intracellular Na+. The increased influx of calcium into the cell produces lower blood levels of calcium and the release of potassium from the cell raises blood levels of potassium. Moreover, if the deficiency is prolonged, the cellular calcium overload may cause calcinosis, due to mixed apatite crystals which combine Ca, P and Mg.”

Magnesium Deficiency, Enzymes, Energy and Detox

“Magnesium is needed by every cell in the body including those of the brain and is one of the most important minerals when considering supplementation because of its vital role in hundreds of enzyme systems and functions related to reactions in cell metabolism, as well as being essential for the synthesis of proteins, for the utilization of fats and carbohydrates.Magnesium is needed not only for the production of specific detoxification enzymes but is also important for energy production related to cell detoxification. A magnesium deficiency can affect virtually every system of the body.”

“Persons only slightly deficient in magnesium become irritable, highly-strung, and sensitive to noise, hyper-excitable, apprehensive and belligerent. If the deficiency is more severe or prolonged, they may develop twitching, tremors, irregular pulse, insomnia, muscle weakness, jerkiness and leg and foot cramps. If magnesium is severely deficient, the brain is particularly affected. Clouded thinking, confusion, disorientation, marked depression and even the terrifying hallucinations of delirium tremens are largely brought on by a lack of this nutrient and remedied when magnesium is given. Because large amounts of calcium are lost in the urine when magnesium is undersupplied, the lack of this nutrient indirectly becomes responsible for much rampant tooth decay, poor bone development, osteoporosis and slow healing of broken bones and fractures. With vitamin B6 (pyridoxine), magnesium helps to reduce and dissolve calcium phosphate kidney stones.”

Possible manifestations of magnesium deficiency include:

  • Low energy
  • Fatigue
  • Weakness
  • Confusion
  • Nervousness
  • Anxiousness
  • Irritability
  • Seizures (and tantrums)
  • Poor digestion
  • PMS and hormonal imbalances
  • Inability to sleep
  • Muscle tension, spasm and cramps
  • Calcification of organs
  • Weakening of the bones
  • Abnormal heart rhythm

Many of the above noted symptoms of Magnesium deficiency are similar to the physical symptoms of Morgellons Disease.

“Magnesium is a crucial factor in the natural self-cleansing and detoxification responses of the body. It stimulates the sodium potassium pump on the cell wall and this initiates the cleansing process in part because the sodium-potassium-ATPase pump regulates intracellular and extracellular potassium levels. Cell membranes contain a sodium/potassium ATPase, a protein that uses the energy of ATP to pump sodium ions out of the cell, and potassium ions into the cell. The pump works all of the time, like a bilge pump in a leaky boat, pumping K+ and Na+ in and out, respectively.”

“Potassium regulation is of course crucial because potassium acts as a counter flow for sodium’s role in nerve transmission. The body must put a high priority on regulating the potassium of the blood serum and this becomes difficult when magnesium levels become deficient.”

“A magnesium deficiency can cause the body to lose potassium and this our bodies cannot afford. Within the cell wall is a sodium pump to provide a high internal potassium and a low internal sodium. Magnesium and potassium inside the cell assist oxidation, and sodium and calcium outside the cell wall help transmit the energy produced.”

“Magnesium in general is essential for the survival of our cells but takes on further importance in the age of toxicity where our bodies are being bombarded on a daily basis with heavy metals. Magnesium thus protects the brain from toxic effects of chemicals.”

Glutathione synthetase requires γ-glutamyl cysteine, glycine, ATP, and magnesium ions to form glutathione.[vii] In magnesium deficiency, the enzyme y-glutamyl transpeptidase is lowered.[viii] Data demonstrates a direct action of glutathione both in vivo and in vitro to enhance intracellular magnesium and a clinical linkage between cellular magnesium, GSH/GSSG ratios, and tissue glucose metabolism.[ix] Magnesium deficiency causes glutathione loss.”

“Magnesium deficiency (MgD) has been associated with production of reactive oxygen species, cytokines, and eicosanoids, as well as vascular compromise in vivo.”

References:

http://jvi.asm.org/

http://jvi.asm.org/cgi/content/abstract/77/1/328

http://jvi.asm.org/cgi/content/full/79/24/15452

http://en.wikipedia.org/wiki/Lysosome

http://www.mgwater.com/durex01.shtml

http://www.advanced-supplements.com/magnesium.html

http://www.magnesiumforlife.com/detox_chelation.shtml

~ by k&k on September 15, 2009.

4 Responses to “Lysosomes – Magnesium – Potassium – Calcium Beneficial for Morgellons Sufferers?”

  1. Excellent Article By the Way

  2. Thanks MRC…

  3. This is very informative article. thanks for sharing.

  4. Wow. This was a difficult read for a layperson, but I certainly got that Magnesium, which I’ve just purchased, as part of my protocol to self-treat for Morgellons, is very necessary. I wonder if you could tell me the dosage amounts for the supplements you’ve discussed.
    Thanks,
    Kristi

    PS The Morgellons is greatly effecting my teeth and gums at this time… MUCH pain and feeling of movement, and black specks are on some of my gums, and into a compromised wisdom tooth which I KNOW I need to get fixed ASAP… terror of dentists…

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